Invited Review NEW INVESTIGATOR AWARD IN REGULATORY AND INTEGRATIVE PHYSIOLOGY Role of Sgk1 in salt and potassium homeostasis
نویسندگان
چکیده
Volker Vallon, Peer Wulff, Dan Yang Huang, Johannes Loffing, Harald Völkl, Dietmar Kuhl, and Florian Lang Departments of Medicine and Pharmacology, University of California, San Diego and Veterans Affairs Medical Center, San Diego, California; Department of Clinical Neurobiology, University of Heidelberg; Departments of Pharmacology and Physiology I, University of Tübingen; Department of Biology, Chemistry and Pharmacy, Free University of Berlin, Germany; Department of Pharmacology, University of Lausanne, Switzerland; Department of Physiology, Innsbruck Medical University, Austria
منابع مشابه
Role of Sgk1 in salt and potassium homeostasis.
Aldosterone plays a pivotal role in NaCl and K(+) homeostasis by stimulation of Na(+) reabsorption and K(+) secretion in the aldosterone-sensitive distal nephron (ASDN). Recent studies demonstrated that the serum- and glucocorticoid-regulated kinase 1 (Sgk1) is induced by aldosterone in the ASDN and that polymorphisms of the kinase associate with arterial blood pressure in normotensive subjects...
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Serum- and glucocorticoid-inducible kinase (SGK1) is transcriptionally upregulated by mineralocorticoids and activated by insulin. The kinase stimulates the renal epithelial Na(+) channel and may thus participate in blood pressure regulation. Hyperinsulinemia is triggered by dietary fructose, which sensitizes blood pressure for salt intake. The role of SGK1 in hypertensive effects of combined f...
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IN THIS ISSUE of the American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, the most recent recipient of the New Investigator Award in Regulatory and Integrative Physiology, Dr. V. Vallon of the Departments of Medicine and Pharmacology at the University of California San Diego and Veterans Affairs Medical Center San Diego, reviews evidence supporting a central role f...
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